How systematic reviews and meta-analyses based on individual participant data can inform trial design and conduct
نویسندگان
چکیده
Introduction Systematic reviews and meta-analyses provide an objective and reliable way of summarising trial results, and can inform both clinical practice and the design, conduct and reporting of trials. However, those based on aggregate data are sometimes limited by the availability of such data, while those based on more comprehensive individual participant data (IPD) can provide more detailed and reliable results. Also, IPD meta-analyses provide a resource for secondary hypothesis testing, which can produce further clinical insight, and rely on close collaboration with trials organisations worldwide. Thus, IPD meta-analyses have the potential to better inform new and on-going trials.
منابع مشابه
How individual participant data meta-analyses have influenced trial design, conduct, and analysis
OBJECTIVES To demonstrate how individual participant data (IPD) meta-analyses have impacted directly on the design and conduct of trials and highlight other advantages IPD might offer. STUDY DESIGN AND SETTING Potential examples of the impact of IPD meta-analyses on trials were identified at an international workshop, attended by individuals with experience in the conduct of IPD meta-analyses...
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